Late last week there were rumors and tons of speculation when it was announced that ABC was developing a spin-off series from AoS. I hesitate to report things at the rumor phase, and I was hoping more details would be revealed soon, and now some have. Maybe... or it's just more rumor to see how people react.
The addition of Bobbi Morse (a major SHIELD character from the comics) and Lance Hunter have been a great new dynamic this season. I'd hate to pull them out of AoS already - they were just settling in to the chemistry of the show. Also, why spin-off ANOTHER AoS spy show?
There is a much more obvious choice that would make a show with a different shape all together with the Inhumans. I know they are getting movie in 2019, so that may not be the best choice, but there is a storyline in the comics where Quake (Skye/Daisy) leads a team of powered individuals for Fury called the "Secret Warriors" - which seems to fit in more with the current schism in the AoS universe.
You CAN have too much of a good thing...